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The compound has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies as they are both believed to be prodrugs of psilocin.[1] Its structural similarities to psilocin and psilocybin results in an identical subjective effect profile and the three compounds can be said to feel indistinguishable from each other. This allows 4-AcO-DMT to function as a perfect substitute for psilocybin mushrooms. 4-ACO-DMT for sale and several other esters of psilocin were originally patented on January 16, 1963 by Sandoz Ltd. via Albert Hofmann & Franz Troxler. Despite this fact, 4-AcO-DMT remains a psychedelic with a limited history of use prior to its release as a grey area compound on the online research chemical market. 4-ACO-DMT ‘s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. 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